Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.68 |
| ▸ | DRD3 | P35462 | 6/20 | 0.68 |
| ▸ | DRD4 | P21917 | 5/20 | 0.68 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.37 |
| ▸ | RELA | Q04206 | 2/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312627 | 0.87 | DRD2 (0.81) | DRD2DRD3DRD4NFKB1NFKB2 | |
| SCHEMBL8312005 | 0.81 | DRD2 (1.00) | DRD2DRD3DRD4NFKB1NFKB2 | |
| SCHEMBL8314369 | 0.79 | DRD2 (0.81) | DRD2DRD3DRD4NFKB1NFKB2 | |
| SCHEMBL8314007 | 0.79 | DRD2 (0.81) | DRD2DRD3DRD4SLC6A4NFKB1 | |
| SCHEMBL8313970 | 0.79 | DRD2 (0.77) | DRD2DRD3DRD4NFKB1NFKB2 | |
| SCHEMBL8317510 | 0.74 | DRD2 (0.64) | DRD2DRD3DRD4SLC6A4HTR1D | |
| SCHEMBL8643128 | 0.74 | DRD2 (0.64) | DRD2DRD3DRD4SLC6A4HTR1D | |
| SCHEMBL8313621 | 0.74 | DRD2 (0.53) | DRD2DRD3DRD4SLC6A4HTR1D | |
| SCHEMBL5957139 | 0.69 | DRD2 (0.55) | DRD2DRD3DRD4SLC6A4HTR2A | |
| SCHEMBL23607588 | 0.64 | MEN1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771801-B1 | Chromane derivatives | AMERICAN HOME PROD (US) | 1999-03-03 | — | — | EP | claimed |
| EP-0771801-A1 | Chromane derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-07 | — | — | EP | claimed |
| EP-0926146-A1 | CHROMENE COMPOUNDS | TOKUYAMA CORPORATION (JP) | 1999-06-30 | — | — | EP | disclosed |
| EP-0771801-B1 | Chromane derivatives | AMERICAN HOME PROD (US) | 1999-03-03 | — | — | EP | disclosed |