Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.64 |
| ▸ | DRD3 | P35462 | 5/20 | 0.64 |
| ▸ | DRD4 | P21917 | 4/20 | 0.64 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | ALPG | P10696 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CMA1 | P23946 | 2/20 | 0.34 |
| ▸ | AHR | P35869 | 2/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8643128 | 0.87 | DRD2 (0.64) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL8312005 | 0.78 | DRD2 (1.00) | DRD2DRD3DRD4 | |
| SCHEMBL8313621 | 0.77 | DRD2 (0.53) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL8312627 | 0.77 | DRD2 (0.81) | DRD2DRD3DRD4 | |
| SCHEMBL8314369 | 0.77 | DRD2 (0.81) | DRD2DRD3DRD4 | |
| SCHEMBL8314007 | 0.77 | DRD2 (0.81) | DRD2DRD3DRD4SLC6A4HTR2A | |
| SCHEMBL3026960 | 0.76 | DRD2 (0.42) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL3032121 | 0.76 | DRD2 (0.42) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL6082416 | 0.76 | DRD2 (0.38) | DRD2DRD3DRD4HTR1D | |
| Water SCHEMBL3032078 | 0.75 | DRD2 (0.41) | DRD2DRD3DRD4HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-9169764-A | — | — | None | — | — | JP | disclosed |
| EP-0771801-B1 | Chromane derivatives | AMERICAN HOME PROD (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5750556-A | REDUCING DOPAMINE SYNTHESIS AND RELEASE, SCHIZOPHRENIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-05-12 | — | — | US | disclosed |
| JP-H09169764-A | 2-(AMINOMETHYL)-3,4,7,9-TETRAHYDRO-2H-PYRANO(2,3-E) INDOL-8-ONE AND DERIVATIVE OF THE SAME | AMERICAN HOME PROD CORP | 1997-06-30 | — | — | JP | disclosed |
| EP-0771801-A1 | Chromane derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-07 | — | — | EP | disclosed |