Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.71 |
| ▸ | HTR2A | P28223 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20577435 | 0.91 | HTR2A (0.71) | KCNH2HTR2AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL11519875 | 0.87 | KCNH2 (0.62) | KCNH2HTR2AHRH3 | |
| SCHEMBL7250766 | 0.87 | KCNH2 (0.72) | KCNH2HTR2AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL9726195 | 0.86 | HTR2A (0.69) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11521416 | 0.86 | MGLL (0.54) | KCNH2HTR2AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL29448592 | 0.86 | KCNH2 (0.69) | KCNH2HTR2AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL11749648 | 0.84 | HSD11B1 (0.54) | KCNH2HTR2AKDM4ECYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL9650868 | 0.83 | HTR2A (0.82) | KCNH2HTR2AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL7368435 | 0.83 | HTR2A (0.83) | KCNH2HTR2AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL24135454 | 0.82 | KCNH2 (0.79) | KCNH2HTR2AKDM4ECYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0536419-B1 | TRICYCLIC TRIAZOLE DERIVATIVES, PRODUCTION AND USE THEREOF | TORAY INDUSTRIES (JP) | 1999-10-13 | — | — | EP | disclosed |
| US-5683998-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, ANTIPAF AGENTS | TORAY INDUSTRIES, INC. (JP) | 1997-11-04 | — | — | US | disclosed |
| CN-1033327-C | Process for preparing tricyclotriazolo derivatives and their use | TORAY INDUSTRIES (JP) | 1996-11-20 | — | — | CN | disclosed |
| EP-0536419-A1 | TRICYCLIC TRIAZOLE DERIVATIVE, PRODUCTION THEREOF, AND USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 1993-04-14 | — | — | EP | disclosed |
| CN-1066849-A | Three ring triazolo derivatives, its Manufacturing approach and use | TORAY INDUSTRIES (JP) | 1992-12-09 | — | — | CN | disclosed |
| US-4151285-A | ANTICONVULSANT, ANTI-ANXIETY AGENTS | A. H. ROBINS COMPANY, INC. (US) | 1979-04-24 | — | — | US | disclosed |