Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8313753 | 1.00 | KDM4E (0.34) | KDM4ENPC1RAB9AKAT8MAPT | |
| SCHEMBL8316004 | 0.87 | FGF23 (0.36) | KDM4ENPC1RAB9AMAPTMEN1 | |
| SCHEMBL8316008 | 0.87 | FGF23 (0.36) | KDM4ENPC1RAB9AMAPTMEN1 | |
| SCHEMBL8310781 | 0.86 | RAB9A (0.38) | KDM4ENPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL8310785 | 0.86 | RAB9A (0.38) | KDM4ENPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL8315650 | 0.86 | LMNA (0.39) | KDM4ENPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL8315652 | 0.86 | LMNA (0.39) | KDM4ENPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL8315608 | 0.86 | CHAT (0.36) | NPC1RAB9AMAPTALDH1A1MEN1 | |
| SCHEMBL8315610 | 0.86 | CHAT (0.36) | NPC1RAB9AMAPTALDH1A1MEN1 | |
| SCHEMBL8317001 | 0.84 | KDM4E (0.42) | KDM4ENPC1RAB9AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3047188-A | — | — | None | — | — | JP | disclosed |
| JP-3206042-A | — | — | None | — | — | JP | disclosed |
| EP-0351856-B1 | Thiazolo[5,4-b]azepine compounds | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-09-15 | — | — | EP | disclosed |
| US-5300639-A | 2-oxo-3-carbonylamino-substituted azepine intermediates; lipoperoxide formation inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-04-05 | — | — | US | disclosed |
| US-5118806-A | Enzyme inhibitor for lipoxygenase; useful for treating cancer, hepatic diseases, inflammation, cerebrovascular diseases | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-06-02 | — | — | US | disclosed |
| JP-H03206042-A | HYPOTENSOR | TAKEDA CHEM IND LTD | 1991-09-09 | — | — | JP | disclosed |
| JP-H0347188-A | THIAZOLO(5,4-B)AZEPINE DERIVATIVE | TAKEDA CHEM IND LTD | 1991-02-28 | — | — | JP | disclosed |
| US-4956360-A | LIPOPEROXIDE INHIBITORS, ENZYME INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-09-11 | — | — | US | disclosed |
| EP-0351856-A2 | Thiazolo[5,4-b]azepine compounds | Takeda Chemical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |