SCHEMBL8314482

SCHEMBL8314482

O=C(NNc1ccc([N+](=O)[O-])cc1)C(F)F

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 10/20 0.55
GAA P10253 8/20 0.55
MAPT P10636 7/20 0.55
KMT2A Q03164 5/20 0.55
MEN1 O00255 3/20 0.55
TDP1 Q9NUW8 3/20 0.55
KDM4E B2RXH2 1/20 0.55
POLB P06746 1/20 0.55
SMN1; SMN2 Q16637 6/20 0.52
LMNA P02545 2/20 0.52
ALOX12 P18054 2/20 0.52
HTT P42858 2/20 0.52
HPGD P15428 2/20 0.52
PKM P14618 1/20 0.52
MAPK1 P28482 1/20 0.51
NPC1 O15118 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
GLA P06280 1/20 0.47
RECQL P46063 1/20 0.46
HSD17B10 Q99714 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20984965 0.80 GAA (0.63) ALDH1A1GAAMAPTKMT2AMEN1
SCHEMBL28030547 0.79 ALDH1A1 (0.66) ALDH1A1GAAMAPTKMT2AMEN1
SCHEMBL424545 0.77 ALDH1A1 (0.59) ALDH1A1GAAMAPTKMT2AMEN1
SCHEMBL3164409 0.77 ALDH1A1 (0.59) ALDH1A1GAAMAPTKMT2AMEN1
SCHEMBL11685105 0.77 ALDH1A1 (0.58) ALDH1A1GAAMAPTKMT2AMEN1
SCHEMBL9193599 0.77 ALDH1A1 (0.58) ALDH1A1GAAMAPTKMT2AMEN1
SCHEMBL16986581 0.75 ALDH1A1 (0.67) ALDH1A1GAAMAPTKMT2AMEN1
SCHEMBL9188891 0.75 PTGS2 (0.51) ALDH1A1GAAMAPTTDP1POLB
SCHEMBL2233218 0.75 ALDH1A1 (0.56) ALDH1A1GAAMAPTKMT2AMEN1
SCHEMBL9188482 0.74 GAA (0.66) ALDH1A1GAAMAPTTDP1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0782042-B1 Hydrazine compound and silver halide photographic photosensitive material comprising the same FUJI PHOTO FILM CO LTD (JP) 1999-12-01 EP disclosed
EP-0782041-B1 Silver halide photographic light-sensitive material FUJI PHOTO FILM CO LTD (JP) 1999-11-17 EP disclosed
US-5789139-A STORAGE STABILITY FUJI PHOTO FILM CO., LTD. (JP) 1998-08-04 US disclosed
US-5770344-A AROMATIC HYDRAZIDE DERIVATIVE; HIGH CONTRAST; PROCESSING AND STORAGE STABILITY; GRAPHIC ARTS FUJI PHOTO FILM CO., LTD. (JP) 1998-06-23 US disclosed
EP-0782042-A2 Hydrazine compound and silver halide photographic photosensitive material comprising the same FUJI PHOTO FILM CO., LTD. (JP) 1997-07-02 EP disclosed
EP-0782041-A2 Silver halide photographic light-sensitive material FUJI PHOTO FILM CO., LTD. (JP) 1997-07-02 EP disclosed