SCHEMBL9188482

SCHEMBL9188482

O=C(NNc1ccccc1)C(F)F

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 10/20 0.66
ALDH1A1 P00352 6/20 0.58
SMN1; SMN2 Q16637 4/20 0.58
LMNA P02545 2/20 0.56
PKM P14618 1/20 0.56
ALOX5 P09917 2/20 0.55
CYP3A4 P08684 2/20 0.55
TSHR P16473 1/20 0.55
PTGS2 P35354 2/20 0.53
KDM4E B2RXH2 1/20 0.48
F2 P00734 1/20 0.47
METAP2 P50579 1/20 0.46
CTSD P07339 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
CRHR1 P34998 1/20 0.43
CYP1A2 P05177 1/20 0.43
MAPT P10636 1/20 0.43
CYP2C9 P11712 1/20 0.43
HPGD P15428 1/20 0.43
ALOX12 P18054 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10117735 0.81 GAA (0.68) GAAALDH1A1SMN1; SMN2LMNAPKM
SCHEMBL8313839 0.80 MAPT (0.45) GAAALDH1A1SMN1; SMN2LMNAPKM
SCHEMBL9188891 0.80 PTGS2 (0.51) GAAALDH1A1SMN1; SMN2LMNAPKM
SCHEMBL6570519 0.79 GAA (1.00) GAAALDH1A1SMN1; SMN2LMNAPKM
SCHEMBL1703604 0.78 POLB (0.61) GAAALDH1A1SMN1; SMN2LMNATSHR
SCHEMBL27822637 0.76 GAA (0.72) GAAALDH1A1SMN1; SMN2LMNAPKM
SCHEMBL8622747 0.76 GAA (0.72) GAAALDH1A1SMN1; SMN2LMNAPKM
SCHEMBL13434772 0.75 ALDH1A1 (0.69) GAAALDH1A1SMN1; SMN2LMNAALOX5
SCHEMBL294587 0.75 TSHR (0.67) GAAALDH1A1SMN1; SMN2LMNAALOX5
SCHEMBL3724442 0.75 ALOX5 (0.67) GAAALDH1A1SMN1; SMN2LMNAALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0596983-B1 MONO- AND DIFLUOROACETYLPHENYL HYDRAZINE COMPOUNDS AS SILVER HALIDE ADJUVANTS DU PONT (US) 1995-11-02 EP claimed
EP-0596983-A1 MONO- AND DIFLUOROACETYLPHENYL HYDRAZINE COMPOUNDS AS SILVER HALIDE ADJUVANTS. DU PONT (US) 1994-05-18 EP claimed
US-5252426-A Lithogrpahic film coated with silver halide emulsions can produce high contrast images E. I. DU PONT DE NEMOURS AND COMPANY (US) 1993-10-12 US claimed
WO-1993003414-A1 MONO- AND DIFLUOROACETYLPHENYL HYDRAZINE COMPOUNDS AS SILVER HALIDE ADJUVANTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-02-18 WO claimed
EP-0596983-B1 MONO- AND DIFLUOROACETYLPHENYL HYDRAZINE COMPOUNDS AS SILVER HALIDE ADJUVANTS DU PONT (US) 1995-11-02 EP disclosed
EP-0596983-A1 MONO- AND DIFLUOROACETYLPHENYL HYDRAZINE COMPOUNDS AS SILVER HALIDE ADJUVANTS. DU PONT (US) 1994-05-18 EP disclosed
WO-1993003414-A1 MONO- AND DIFLUOROACETYLPHENYL HYDRAZINE COMPOUNDS AS SILVER HALIDE ADJUVANTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-02-18 WO disclosed