Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.45 |
| ▸ | CTSD | P07339 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318294 | 0.82 | EGFR (0.46) | EGFRCTSDBACE1BACE2 | |
| SCHEMBL6994593 | 0.82 | ABCG2 (0.54) | EGFR | |
| SCHEMBL8319085 | 0.82 | EGFR (0.44) | EGFR | |
| SCHEMBL6997375 | 0.79 | EGFR (0.47) | EGFRBRAFERBB2HPGDHTT | |
| SCHEMBL8317145 | 0.79 | EGFR (0.49) | EGFRERBB2HPGDHTT | |
| SCHEMBL8484295 | 0.78 | EGFR (0.53) | EGFRERBB2 | |
| SCHEMBL6417047 | 0.77 | EGFR (0.66) | EGFRERBB2HTT | |
| SCHEMBL6993872 | 0.77 | EGFR (0.69) | EGFRHTT | |
| SCHEMBL6992072 | 0.77 | EGFR (0.44) | EGFRBRAFERBB2HPGDHTT | |
| SCHEMBL8486684 | 0.77 | EGFR (0.46) | EGFRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |