Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 13/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | F9 | P00740 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6995062 | 0.89 | EGFR (0.51) | ABCG2EGFRSYK | |
| SCHEMBL6993872 | 0.84 | EGFR (0.69) | EGFR | |
| SCHEMBL8320084 | 0.84 | EGFR (0.70) | EGFR | |
| SCHEMBL8315330 | 0.84 | EGFR (0.57) | EGFRTP53 | |
| SCHEMBL8314880 | 0.84 | EGFR (0.53) | ABCG2EGFR | |
| SCHEMBL6417047 | 0.83 | EGFR (0.66) | ABCG2EGFRDYRK1ADYRK1B | |
| SCHEMBL8314779 | 0.82 | EGFR (0.45) | EGFR | |
| SCHEMBL8320237 | 0.82 | EGFR (0.55) | ABCG2EGFRDYRK1ADYRK1B | |
| SCHEMBL8315829 | 0.82 | EGFR (0.51) | EGFR | |
| SCHEMBL6990835 | 0.81 | EGFR (0.50) | EGFRSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-B1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | THOMAE GMBH DR K (DE) | 2003-10-15 | — | — | EP | disclosed |