Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22418804 | 0.83 | L3MBTL1 (0.43) | KMT2AALOX5LMNAAOC3TDP1 | |
| SCHEMBL173884 | 0.83 | L3MBTL1 (0.43) | KMT2AALOX5LMNAAOC3TDP1 | |
| SCHEMBL14246913 | 0.82 | KMT2A (0.47) | MAPTKMT2AALOX5LMNAADRA2A | |
| SCHEMBL6017678 | 0.82 | MAPT (0.50) | MAPTKMT2AALOX5LMNAAOC3 | |
| SCHEMBL2439195 | 0.82 | L3MBTL1 (0.42) | KMT2AALOX5LMNAAOC3TDP1 | |
| SCHEMBL2439196 | 0.82 | L3MBTL1 (0.42) | KMT2AALOX5LMNAAOC3TDP1 | |
| SCHEMBL16892954 | 0.82 | ALOX5 (0.48) | MAPTKMT2AALOX5LMNAADRA2A | |
| SCHEMBL2439193 | 0.82 | L3MBTL1 (0.42) | KMT2AALOX5LMNAAOC3TDP1 | |
| SCHEMBL28810022 | 0.81 | ROCK2 (0.41) | KMT2ALMNAPTGS2L3MBTL1CYP1A2 | |
| SCHEMBL17520105 | 0.81 | MAPT (0.46) | MAPTKMT2AALOX5LMNAAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0730587-B1 | 3-PHENYL-2-ISOXAZOLINES AS ANTIINFLAMMATORY AGENTS | PFIZER (US) | 1999-12-08 | — | — | EP | disclosed |
| US-5686434-A | PHOSPHODIESTERASE TYPE IV INHIBITORS | PFIZER INC. (US) | 1997-11-11 | — | — | US | disclosed |