Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311219 | 0.86 | CYP19A1 (0.40) | CYP19A1PTGS2KDM4EALDH1A1HSD17B10 | |
| Bicarbonate SCHEMBL8005963 | 0.79 | POLB (0.36) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL8312811 | 0.78 | CYP19A1 (0.40) | SERPINE1CYP19A1KDM4EALDH1A1HPGD | |
| SCHEMBL8315306 | 0.77 | CYP19A1 (0.42) | CYP19A1PTGS2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL8315322 | 0.74 | CYP19A1 (0.41) | CYP19A1PTGS2KDM4EALDH1A1HSD17B10 | |
| Bicarbonate SCHEMBL8019312 | 0.73 | GRM1 (0.33) | KDM4EALDH1A1HSD17B10HPGDEPHX2 | |
| SCHEMBL8019597 | 0.72 | KDM4E (0.35) | KDM4EALDH1A1GAAPOLBMEN1 | |
| SCHEMBL8707406 | 0.72 | KCNQ3 (0.33) | KDM4EALDH1A1NPSR1EPHX2POLB | |
| SCHEMBL8015561 | 0.72 | LTC4S (0.36) | KDM4EGAAPOLBMAPT | |
| SCHEMBL8704063 | 0.71 | POLB (0.38) | KDM4EPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647637-B1 | 3-Aryl-4-hydroxy-3-dihydrofuranone derivatives | BAYER AG (DE) | 1999-01-27 | — | — | EP | disclosed |
| EP-0647637-A1 | 3-Aryl-4-hydroxy-3-dihydrofuranone derivatives | BAYER AG (DE) | 1995-04-12 | — | — | EP | disclosed |