Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 6/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8315306 | 0.84 | CYP19A1 (0.42) | CYP19A1KDM4EHTTSMN1; SMN2MAPT | |
| SCHEMBL8311219 | 0.84 | CYP19A1 (0.40) | CYP19A1KDM4EMAPTALDH1A1HPGD | |
| SCHEMBL8578647 | 0.79 | MEN1 (0.31) | GAAALDH1A1L3MBTL1NLRP3POLB | |
| SCHEMBL8314893 | 0.74 | SERPINE1 (0.38) | CYP19A1KDM4EHTTSMN1; SMN2MAPT | |
| SCHEMBL8312811 | 0.70 | CYP19A1 (0.40) | CYP19A1APOBEC3AAPOBEC3GKDM4EHTT | |
| SCHEMBL2167246 | 0.70 | NLRP3 (0.51) | KDM4EHTTSMN1; SMN2GAAALDH1A1 | |
| SCHEMBL769278 | 0.68 | GAA (0.48) | KDM4ESMN1; SMN2MAPTGAAALDH1A1 | |
| SCHEMBL11471989 | 0.68 | KDM4E (0.44) | CYP19A1KDM4EHTTSMN1; SMN2MAPT | |
| SCHEMBL22372971 | 0.68 | MEN1 (0.35) | KDM4EMAPTGAAALDH1A1HSD17B10 | |
| SCHEMBL13168053 | 0.65 | KDM4E (0.41) | KDM4EMAPTALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647637-B1 | 3-Aryl-4-hydroxy-3-dihydrofuranone derivatives | BAYER AG (DE) | 1999-01-27 | — | — | EP | disclosed |
| EP-0647637-A1 | 3-Aryl-4-hydroxy-3-dihydrofuranone derivatives | BAYER AG (DE) | 1995-04-12 | — | — | EP | disclosed |