Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 6/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311219 | 0.88 | CYP19A1 (0.40) | CYP19A1NLRP3P2RX7ALDH1A1HSD17B10 | |
| SCHEMBL8315322 | 0.84 | CYP19A1 (0.41) | CYP19A1NLRP3P2RX7ALDH1A1HSD17B10 | |
| SCHEMBL8579826 | 0.78 | MEN1 (0.33) | NLRP3P2RX7ALDH1A1HSD17B10HPGD | |
| SCHEMBL8314893 | 0.77 | SERPINE1 (0.38) | CYP19A1ALDH1A1HSD17B10HPGDKDM4E | |
| SCHEMBL2167246 | 0.77 | NLRP3 (0.51) | NLRP3ALDH1A1HSD17B10HPGDKDM4E | |
| SCHEMBL8090780 | 0.74 | MMP1 (0.32) | NLRP3P2RX7 | |
| SCHEMBL8312811 | 0.74 | CYP19A1 (0.40) | CYP19A1P2RX7ALDH1A1HPGDKDM4E | |
| Bicarbonate SCHEMBL8848396 | 0.73 | CHRM2 (0.34) | P2RX7KDM4EPOLBMAPT | |
| SCHEMBL1688859 | 0.72 | CYP1A2 (0.52) | ALDH1A1HSD17B10SMN1; SMN2ALOX15TSHR | |
| SCHEMBL769278 | 0.71 | GAA (0.48) | NLRP3ALDH1A1HSD17B10HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647637-B1 | 3-Aryl-4-hydroxy-3-dihydrofuranone derivatives | BAYER AG (DE) | 1999-01-27 | — | — | EP | disclosed |
| EP-0647637-A1 | 3-Aryl-4-hydroxy-3-dihydrofuranone derivatives | BAYER AG (DE) | 1995-04-12 | — | — | EP | disclosed |