Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 7/20 | 0.48 |
| ▸ | HTR1B | P28222 | 6/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 3/20 | 0.35 |
| ▸ | HTR7 | P34969 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9668693 | 0.71 | HTR6 (0.58) | HTR1DHTR1BCHRM3CHRM2CHRM1 | |
| SCHEMBL6542148 | 0.69 | CHRM3 (0.61) | HTR1DHTR1BCHRM3CHRM2CHRM1 | |
| SCHEMBL9669655 | 0.68 | HTR1D (0.51) | HTR1DHTR1BCHRM3CHRM2CHRM1 | |
| SCHEMBL9186774 | 0.66 | CHRM3 (0.57) | HTR1DHTR1BCHRM3CHRM2CHRM1 | |
| SCHEMBL8313653 | 0.65 | HTR1D (1.00) | HTR1DHTR1BHTR1A | |
| SCHEMBL14591308 | 0.64 | CHRM3 (0.69) | HTR1DHTR1BCHRM3CHRM2CHRM1 | |
| SCHEMBL8890307 | 0.64 | HTR2A (0.50) | CHRM3CHRM2CHRM1DRD2DRD3 | |
| SCHEMBL10978045 | 0.64 | HTR6 (0.60) | HTR1DHTR1BCHRM3CHRM2CHRM1 | |
| SCHEMBL8891132 | 0.63 | CHRM3 (1.00) | HTR1DHTR1BCHRM3CHRM2CHRM1 | |
| SCHEMBL6540873 | 0.63 | CHRM3 (0.67) | HTR1DHTR1BCHRM3CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510068-B1 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | UPJOHN CO (US) | 1999-04-14 | — | — | EP | disclosed |
| US-5650427-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1997-07-22 | — | — | US | disclosed |
| US-5461061-A | Antidepressants | WIKSTROM HAKAN V (NL) | 1995-10-24 | — | — | US | disclosed |
| US-5288748-A | Antidepressants | THE UPJOHN COMPANY (US) | 1994-02-22 | — | — | US | disclosed |
| WO-1991011435-A2 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | THE UPJOHN COMPANY (US) | 1991-08-08 | — | — | WO | disclosed |