Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.58 |
| ▸ | HTR1D | P28221 | 6/20 | 0.49 |
| ▸ | HTR1B | P28222 | 5/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9670304 | 0.84 | DRD3 (0.62) | HTR1DHTR1BDRD3DRD2 | |
| SCHEMBL10978045 | 0.81 | HTR6 (0.60) | HTR6HTR1DHTR1BCHRM3DRD3 | |
| SCHEMBL9669337 | 0.79 | HTR1D (0.60) | HTR1DHTR1BDRD3DRD2 | |
| SCHEMBL3205572 | 0.74 | HTR6 (1.00) | HTR6DRD3DRD2 | |
| SCHEMBL3259947 | 0.74 | HTR6 (0.63) | HTR6HTR1DHTR1BCHRM3 | |
| SCHEMBL9668655 | 0.74 | DRD3 (0.40) | HTR6HTR1DHTR1BDRD3DRD2 | |
| SCHEMBL13422076 | 0.73 | HTR6 (0.82) | HTR6HTR1DHTR1B | |
| SCHEMBL3198489 | 0.72 | HTR6 (0.80) | HTR6 | |
| SCHEMBL8314905 | 0.71 | HTR1D (0.48) | HTR6HTR1DHTR1BCHRM3DRD3 | |
| SCHEMBL3212926 | 0.71 | HTR6 (0.74) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510068-A1 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | PHARMACIA & UPJOHN COMPANY (US) | 1992-10-28 | — | — | EP | claimed |