Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316617 | 1.00 | KDM4E (0.39) | KDM4EPOLBALDH1A1ESR1CHRM1 | |
| SCHEMBL8455247 | 0.91 | CA12 (0.40) | KDM4EALDH1A1ESR1TSHRLMNA | |
| SCHEMBL8799968 | 0.71 | OPRM1 (0.35) | KDM4EALDH1A1TDP1MAPTKMT2A | |
| SCHEMBL9050223 | 0.71 | HTR2C (0.43) | MAPTOPRM1AKR1B1 | |
| SCHEMBL9055539 | 0.69 | AKR1B1 (0.46) | ALDH1A1KMT2AMEN1SMN1; SMN2AKR1B1 | |
| SCHEMBL9055459 | 0.67 | OPRD1 (0.41) | SLC6A2OPRM1AKR1B1 | |
| SCHEMBL8800284 | 0.67 | OPRD1 (0.41) | SLC6A2OPRM1AKR1B1 | |
| SCHEMBL8314963 | 0.66 | HTR1D (0.42) | KDM4EPOLBALDH1A1ESR1CHRM1 | |
| SCHEMBL17238261 | 0.65 | ALDH1A1 (0.50) | KDM4EPOLBALDH1A1ESR1CHRM1 | |
| SCHEMBL11512861 | 0.65 | ALDH1A1 (0.47) | KDM4EPOLBALDH1A1ESR1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889892-A1 | AZASPIRO DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1999-01-13 | — | — | EP | disclosed |
| WO-1997035861-A1 | AZASPIRO DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1997-10-02 | — | — | WO | disclosed |