Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.39 |
| ▸ | TFEB | P19484 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL8315183 | 1.00 | PTGS2 (0.39) | PTGS2PTGS1NFE2L2TFEBRAB9A | |
| SCHEMBL8316364 | 0.94 | PTGS2 (0.41) | PTGS2PTGS1NFE2L2TFEBRAB9A | |
| SCHEMBL8316367 | 0.94 | PTGS2 (0.41) | PTGS2PTGS1NFE2L2TFEBRAB9A | |
| SCHEMBL8316370 | 0.94 | PTGS2 (0.41) | PTGS2PTGS1NFE2L2TFEBRAB9A | |
| Oxalic Acid SCHEMBL8313128 | 0.86 | CYP1A1 (0.40) | RAB9ANPC1LMNAMAPTKDM4E | |
| Oxalic Acid SCHEMBL8313123 | 0.86 | CYP1A1 (0.40) | RAB9ANPC1LMNAMAPTKDM4E | |
| SCHEMBL8311619 | 0.84 | MAPT (0.44) | NFE2L2RAB9ANPC1MAPTKDM4E | |
| SCHEMBL8311200 | 0.84 | MAPT (0.44) | NFE2L2RAB9ANPC1MAPTKDM4E | |
| Oxalic Acid SCHEMBL8315279 | 0.82 | ALDH1A1 (0.37) | RAB9ANPC1LMNAMAPTKDM4E | |
| Oxalic Acid SCHEMBL8315277 | 0.82 | ALDH1A1 (0.37) | RAB9ANPC1LMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351856-B1 | Thiazolo[5,4-b]azepine compounds | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-09-15 | — | — | EP | disclosed |