Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2J2 | P51589 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 5/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8313333 | 0.98 | HRH1 (0.43) | CYP2J2POLBSMN1; SMN2HRH1KCNH2 | |
| SCHEMBL8317157 | 0.88 | CYP2J2 (0.45) | CYP2J2HRH1KCNH2PAX8MEN1 | |
| SCHEMBL8315418 | 0.87 | PAX8 (0.40) | CYP2J2HRH1KCNH2PAX8HTR1A | |
| SCHEMBL8314774 | 0.87 | CYP2J2 (0.47) | CYP2J2HRH1KCNH2PAX8MEN1 | |
| SCHEMBL8316037 | 0.86 | HRH1 (0.46) | CYP2J2HRH1KCNH2MEN1NPC1 | |
| SCHEMBL8312317 | 0.85 | HRH1 (0.48) | CYP2J2HRH1KCNH2MEN1NPC1 | |
| SCHEMBL8315211 | 0.83 | HRH1 (0.46) | CYP2J2HRH1KCNH2MEN1NPC1 | |
| SCHEMBL8317297 | 0.82 | HRH1 (0.39) | CYP2J2HRH1KCNH2MEN1NPC1 | |
| SCHEMBL8523260 | 0.79 | HRH1 (0.37) | CYP2J2HRH1KCNH2MEN1NPC1 | |
| SCHEMBL8317429 | 0.79 | HRH1 (0.39) | CYP2J2HRH1KCNH2MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0536419-B1 | TRICYCLIC TRIAZOLE DERIVATIVES, PRODUCTION AND USE THEREOF | TORAY INDUSTRIES (JP) | 1999-10-13 | — | — | EP | disclosed |