SCHEMBL8315510

SCHEMBL8315510

CN(C)C=NS(=O)(=O)CCC(C)(C)CCI

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.31
GAA P10253 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8315506 1.00 LMNA (0.31) LMNAGAA
SCHEMBL8556475 0.90
SCHEMBL8556470 0.90
SCHEMBL8312546 0.90 LMNA (0.31) LMNAGAA
SCHEMBL8312545 0.90 LMNA (0.31) LMNAGAA
SCHEMBL8316411 0.85 LMNA (0.30) LMNAGAA
SCHEMBL8311675 0.83 LMNA (0.31) LMNAGAA
SCHEMBL8314611 0.82
SCHEMBL8314607 0.82
SCHEMBL8311327 0.81 NLRP3 (0.32) LMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0562439-B1 Triazolopyridazines as antioasthmatics TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1999-06-09 EP disclosed
EP-0548923-B1 Antiallergic, antiinflammatory and anti-PAF pyridazine compounds TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1998-07-08 EP disclosed
US-5482939-A ANTI-PLATELET ACTIVATING FACTOR ACTIVITIES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-01-09 US disclosed
US-5389633-A ANTIASTHMATIC AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-02-14 US disclosed
US-5369104-A Antiasthmatic agents TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1994-11-29 US disclosed
EP-0562439-A1 Triazolopyridazines as antioasthmatics TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-09-29 EP disclosed
EP-0548923-A2 Antiallergic, antiinflammatory and anti-PAF pyridazine compounds TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-06-30 EP disclosed