Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FBP1 | P09467 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | ABL2 | P42684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6993872 | 0.87 | EGFR (0.69) | EGFR | |
| SCHEMBL8315330 | 0.86 | EGFR (0.57) | EGFRLCKFBP1ABL1ABL2 | |
| SCHEMBL8320084 | 0.86 | EGFR (0.70) | EGFR | |
| SCHEMBL8318188 | 0.86 | EGFR (0.55) | EGFRABCG2 | |
| SCHEMBL6417047 | 0.86 | EGFR (0.66) | EGFRABCG2AURKBABL1 | |
| SCHEMBL6997375 | 0.85 | EGFR (0.47) | EGFR | |
| SCHEMBL8315829 | 0.84 | EGFR (0.51) | EGFR | |
| SCHEMBL8320237 | 0.84 | EGFR (0.55) | EGFRABCG2AURKB | |
| SCHEMBL6994593 | 0.84 | ABCG2 (0.54) | EGFRABCG2 | |
| SCHEMBL6990835 | 0.84 | EGFR (0.50) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |