Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7904695 | 0.89 | F2 (0.42) | F2RAB9AKMT2AKDM4EHTT | |
| SCHEMBL9278446 | 0.73 | RAB9A (0.44) | F2RAB9AKMT2AKDM4EMEN1 | |
| SCHEMBL9471997 | 0.73 | RAB9A (0.42) | F2RAB9AKMT2AKDM4EMEN1 | |
| SCHEMBL7904670 | 0.72 | KDM1A (0.39) | RAB9AKMT2AKDM4EMEN1NPC1 | |
| SCHEMBL18207466 | 0.67 | USP28 (0.47) | USP28KMT2AMEN1ADORA3POLB | |
| SCHEMBL18207312 | 0.61 | TLR7 (0.68) | RAB9AUSP28GAAHTTNPC1 | |
| SCHEMBL18207325 | 0.61 | TLR7 (0.43) | USP28POLB | |
| SCHEMBL7904638 | 0.60 | MEN1 (0.38) | RAB9AKMT2AKDM4EMEN1HTT | |
| SCHEMBL18207586 | 0.59 | TLR7 (0.44) | RAB9AUSP28KMT2AMEN1NPC1 | |
| SCHEMBL19134086 | 0.59 | TLR7 (0.46) | USP28POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958294-A1 | 2-(1,2,4-TRIAZOLE-1-YL)-1,3,4-THIADIAZOLE DERIVATIVES HAVING AN EFFECT ON THE C.N.S. AND THE HEART | EGIS GYOGYSZERGYAR (HU) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998030561-A1 | 2-(1,2,4-TRIAZOLE-1-YL)-1,3,4-THIADIAZOLE DERIVATIVES HAVING AN EFFECT ON THE C.N.S. AND THE HEART | EGIS Gyógyszergyár Rt. (HU) | 1998-07-16 | — | — | WO | disclosed |