Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8310881 | 0.89 | ALDH1A1 (0.39) | KMT2ASMN1; SMN2MEN1GAADRD1 | |
| SCHEMBL8314379 | 0.89 | DRD1 (0.45) | KMT2ASMN1; SMN2MEN1GAADRD1 | |
| SCHEMBL8313446 | 0.89 | KMT2A (0.37) | KMT2ASMN1; SMN2MEN1GAADRD1 | |
| SCHEMBL9538257 | 0.86 | KMT2A (0.49) | KMT2ASMN1; SMN2MEN1GAADRD1 | |
| SCHEMBL8314625 | 0.84 | KMT2A (0.45) | KMT2ASMN1; SMN2MEN1GAADRD1 | |
| SCHEMBL8314818 | 0.83 | KMT2A (0.37) | KMT2ASMN1; SMN2MEN1GAAKDM4E | |
| SCHEMBL8875071 | 0.83 | SMN1; SMN2 (0.53) | KMT2ASMN1; SMN2MEN1GAADRD1 | |
| SCHEMBL8315579 | 0.83 | KMT2A (0.43) | KMT2ASMN1; SMN2MEN1GAADRD1 | |
| SCHEMBL8316443 | 0.83 | KMT2A (0.48) | KMT2ASMN1; SMN2MEN1GAADRD1 | |
| SCHEMBL8317694 | 0.82 | KMT2A (0.43) | KMT2ASMN1; SMN2MEN1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |