Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8313446 | 0.89 | KMT2A (0.37) | KMT2AMEN1OPRK1OPRM1CYP19A1 | |
| SCHEMBL8313957 | 0.89 | ALDH1A1 (0.33) | KMT2AMEN1POLBOPRK1MAPK1 | |
| SCHEMBL8317692 | 0.86 | POLB (0.35) | KMT2AMEN1POLBOPRK1OPRM1 | |
| SCHEMBL9536573 | 0.85 | MEN1 (0.43) | KMT2AMEN1POLBOPRK1OPRM1 | |
| SCHEMBL8310881 | 0.85 | ALDH1A1 (0.39) | KMT2AMEN1POLBOPRK1OPRM1 | |
| SCHEMBL8316437 | 0.83 | MEN1 (0.33) | KMT2AMEN1POLBOPRK1OPRM1 | |
| SCHEMBL8315952 | 0.83 | KMT2A (0.47) | KMT2AMEN1POLBOPRK1OPRM1 | |
| SCHEMBL8317543 | 0.82 | VHL (0.34) | KMT2AMEN1POLBOPRK1MAPK1 | |
| SCHEMBL8313613 | 0.82 | MEN1 (0.36) | KMT2AMEN1POLBHRH3OPRK1 | |
| SCHEMBL8876637 | 0.82 | POLB (0.40) | KMT2AMEN1POLBMAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |