Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CFB | P00751 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8315952 | 0.89 | KMT2A (0.47) | KMT2ASMN1; SMN2MEN1GAAALDH1A1 | |
| SCHEMBL8314818 | 0.89 | KMT2A (0.37) | KMT2ASMN1; SMN2MEN1GAAKDM4E | |
| SCHEMBL8313747 | 0.89 | ALDH1A1 (0.35) | KMT2ASMN1; SMN2MEN1GAAALDH1A1 | |
| SCHEMBL8317474 | 0.83 | KMT2A (0.35) | KMT2ASMN1; SMN2MEN1GAAALDH1A1 | |
| SCHEMBL8310881 | 0.83 | ALDH1A1 (0.39) | KMT2ASMN1; SMN2MEN1GAAALDH1A1 | |
| SCHEMBL8317651 | 0.82 | PIK3CD (0.39) | KMT2ASMN1; SMN2MEN1GAAALDH1A1 | |
| SCHEMBL8875560 | 0.82 | KMT2A (0.43) | KMT2ASMN1; SMN2MEN1GAAALDH1A1 | |
| SCHEMBL8317229 | 0.82 | KMT2A (0.38) | KMT2ASMN1; SMN2MEN1GAAALDH1A1 | |
| SCHEMBL8317692 | 0.82 | POLB (0.35) | KMT2ASMN1; SMN2MEN1GAAALDH1A1 | |
| SCHEMBL8318503 | 0.81 | ALDH1A1 (0.34) | KMT2ASMN1; SMN2MEN1GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |