Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.46 |
| ▸ | BRD2 | P25440 | 2/20 | 0.41 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | APAF1 | O14727 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 4/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319748 | 0.87 | BRD4 (0.46) | BRD4BRD2BRD3LMNAHPGD | |
| SCHEMBL8321540 | 0.85 | BRD4 (0.43) | BRD4BRD2BRD3MAPTGABRA1 | |
| SCHEMBL8320572 | 0.85 | BRD4 (0.49) | BRD4BRD2BRD3PGRLMNA | |
| SCHEMBL8323068 | 0.82 | ALDH1A1 (0.44) | BRD4BRD2BRD3HPGDALDH1A1 | |
| SCHEMBL8320432 | 0.80 | BRD4 (0.44) | BRD4BRD2BRD3LMNANPC1 | |
| SCHEMBL8322223 | 0.79 | BRD4 (0.40) | BRD4MAPTCNR1TSHR | |
| SCHEMBL8317706 | 0.79 | BRD4 (0.52) | BRD4BRD2BRD3LMNAHPGD | |
| SCHEMBL8316213 | 0.79 | BRD4 (0.55) | BRD4BRD2BRD3LMNAHPGD | |
| SCHEMBL8316009 | 0.77 | BRD4 (0.49) | BRD4BRD2BRD3LMNAHPGD | |
| SCHEMBL8318456 | 0.77 | BRD4 (0.55) | BRD4BRD2BRD3LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934940-A1 | CYTOKINE PRODUCTION INHIBITORS, TRIAZEPINE COMPOUNDS, AND INTERMEDIATES THEREOF | Japan Tobacco Inc. (JP) | 1999-08-11 | — | — | EP | claimed |
| EP-0934940-A1 | CYTOKINE PRODUCTION INHIBITORS, TRIAZEPINE COMPOUNDS, AND INTERMEDIATES THEREOF | Japan Tobacco Inc. (JP) | 1999-08-11 | — | — | EP | disclosed |