Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8321540 | 0.91 | BRD4 (0.43) | BRD4CYP11B2CYP11B1CYP19A1MAPT | |
| SCHEMBL8318636 | 0.89 | BRD4 (0.47) | BRD4CYP11B2CYP11B1CYP19A1TSHR | |
| SCHEMBL8320432 | 0.86 | BRD4 (0.44) | BRD4MEN1KMT2A | |
| SCHEMBL8323068 | 0.82 | ALDH1A1 (0.44) | BRD4CYP11B2CYP11B1TSHRMAPT | |
| SCHEMBL8316889 | 0.81 | BRD4 (0.46) | BRD4CNR1MEN1KMT2A | |
| SCHEMBL8314769 | 0.81 | BRD4 (0.46) | BRD4CYP11B2CYP11B1CYP19A1 | |
| SCHEMBL8317706 | 0.81 | BRD4 (0.52) | BRD4CNR1 | |
| SCHEMBL8316021 | 0.80 | OPRK1 (0.41) | BRD4CYP11B2CNR1CCNCCDK8 | |
| SCHEMBL8321315 | 0.80 | BRD4 (0.39) | BRD4CYP11B2CYP11B1CCNCCDK8 | |
| SCHEMBL8318456 | 0.80 | BRD4 (0.55) | BRD4CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934940-A1 | CYTOKINE PRODUCTION INHIBITORS, TRIAZEPINE COMPOUNDS, AND INTERMEDIATES THEREOF | Japan Tobacco Inc. (JP) | 1999-08-11 | — | — | EP | claimed |
| EP-0934940-A1 | CYTOKINE PRODUCTION INHIBITORS, TRIAZEPINE COMPOUNDS, AND INTERMEDIATES THEREOF | Japan Tobacco Inc. (JP) | 1999-08-11 | — | — | EP | disclosed |