Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.45 |
| ▸ | TGM2 | P21980 | 7/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | KLK7 | P49862 | 2/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.39 |
| ▸ | F13A1 | P00488 | 2/20 | 0.39 |
| ▸ | TGM1 | P22735 | 2/20 | 0.39 |
| ▸ | TGM6 | O95932 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316539 | 1.00 | ITGB3 (0.45) | ITGB3ITGA2BTGM2KMT2ACTSL | |
| SCHEMBL8316006 | 0.94 | CTSK (0.41) | ITGB3ITGA2BTGM2KMT2AMAPK1 | |
| SCHEMBL8316003 | 0.94 | CTSK (0.41) | ITGB3ITGA2BTGM2KMT2AMAPK1 | |
| SCHEMBL8314603 | 0.87 | ITGB3 (0.41) | ITGB3ITGA2BTGM2KMT2AMAPK1 | |
| SCHEMBL8314601 | 0.87 | ITGB3 (0.41) | ITGB3ITGA2BTGM2KMT2AMAPK1 | |
| SCHEMBL2577149 | 0.84 | GHSR (0.46) | KMT2AHSD11B1HSD11B2GHSR | |
| SCHEMBL2575425 | 0.84 | GHSR (0.46) | KMT2AHSD11B1HSD11B2GHSR | |
| SCHEMBL2579092 | 0.84 | GHSR (0.46) | KMT2AHSD11B1HSD11B2GHSR | |
| SCHEMBL2575426 | 0.84 | GHSR (0.46) | KMT2AHSD11B1HSD11B2GHSR | |
| SCHEMBL5615551 | 0.84 | GHSR (0.46) | KMT2AHSD11B1HSD11B2GHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662481-B1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO INC (US) | 1999-03-24 | — | — | EP | disclosed |
| US-5578593-A | RELEASING GROWTH HORMONES FOR ANIMALS | MERCK & CO., INC. (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0662481-A1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO. INC. (US) | 1995-07-12 | — | — | EP | disclosed |