Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 6/20 | 0.47 |
| ▸ | MMP9 | P14780 | 5/20 | 0.47 |
| ▸ | MMP13 | P45452 | 4/20 | 0.47 |
| ▸ | MMP8 | P22894 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 3/20 | 0.37 |
| ▸ | MMP7 | P09237 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | MMP10 | P09238 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8321165 | 0.78 | MMP13 (0.44) | MMP2MMP9MMP13MMP8HPGD | |
| SCHEMBL8317677 | 0.77 | MMP2 (0.55) | MMP2MMP9MMP13MMP8HPGD | |
| SCHEMBL6231419 | 0.74 | MMP2 (0.41) | MMP2MMP9MMP13MMP8MMP3 | |
| SCHEMBL6208878 | 0.74 | MMP2 (0.40) | MMP2MMP9MMP13MMP8MMP3 | |
| SCHEMBL8316685 | 0.72 | MMP2 (0.50) | MMP2MMP9MMP13MMP8MMP3 | |
| SCHEMBL6208098 | 0.72 | CYP3A4 (0.41) | MMP2MMP9MMP13MMP8MMP3 | |
| Hydrochloric Acid SCHEMBL6205781 | 0.72 | MMP2 (0.49) | MMP2MMP9MMP13MMP8MMP3 | |
| SCHEMBL8316532 | 0.71 | MMP2 (0.57) | MMP2MMP9MMP13MMP8MMP3 | |
| SCHEMBL6251227 | 0.71 | RAB9A (0.51) | MMP2MMP9MMP13MMP8MAPT | |
| SCHEMBL6207349 | 0.70 | CYP3A4 (0.44) | MMP2MMP9MMP13MMP8MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004048368-A2 | HETEROARYLSULFONYLMETHYL HYDROXAMIC ACIDS AND AMIDES AND THEIR USE AS PROTEASE INHIBITORS | PHARMACIA CORPORATION (US) | 2004-06-10 | — | — | WO | disclosed |