Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318132 | 0.88 | ABCB1 (0.33) | KMT2AMEN1SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL8313464 | 0.88 | NLRP3 (0.33) | KMT2AMEN1SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL8317102 | 0.82 | KMT2A (0.43) | KMT2AMEN1SMN1; SMN2GAADRD1 | |
| SCHEMBL8876471 | 0.81 | KMT2A (0.49) | KMT2AMEN1SMN1; SMN2GAADRD1 | |
| SCHEMBL8316836 | 0.81 | NLRP3 (0.33) | KMT2AMEN1SMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL8318325 | 0.81 | KMT2A (0.39) | KMT2ASMN1; SMN2GAAALDH1A1KDM4E | |
| SCHEMBL8317719 | 0.80 | KMT2A (0.43) | KMT2AMEN1SMN1; SMN2GAADRD1 | |
| SCHEMBL8318010 | 0.78 | KMT2A (0.47) | KMT2AMEN1SMN1; SMN2GAADRD1 | |
| SCHEMBL8316443 | 0.77 | KMT2A (0.48) | KMT2AMEN1SMN1; SMN2GAADRD1 | |
| SCHEMBL8317246 | 0.76 | KMT2A (0.45) | KMT2AMEN1SMN1; SMN2GAADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |