Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 3/20 | 0.42 |
| ▸ | CES1 | P23141 | 3/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8317039 | 1.00 | GABRA1 (0.45) | GABRA1GABRG2GABRB3GABRB2TSHR | |
| SCHEMBL29119462 | 0.85 | TSHR (0.46) | TSHRALOX15SRD5A2KMT2ACA1 | |
| SCHEMBL15991618 | 0.84 | ALDH1A1 (0.47) | CYP19A1CES2SRD5A2CA1CA2 | |
| SCHEMBL15991621 | 0.84 | ALDH1A1 (0.47) | CYP19A1CES2SRD5A2CA1CA2 | |
| SCHEMBL9447416 | 0.84 | ALDH1A1 (0.47) | CES2CES1SRD5A2MEN1KMT2A | |
| SCHEMBL9447417 | 0.84 | ALDH1A1 (0.47) | CES2CES1SRD5A2MEN1KMT2A | |
| SCHEMBL2566020 | 0.83 | ALDH1A1 (0.51) | TSHRCYP19A1CES2CES1MEN1 | |
| SCHEMBL3289274 | 0.83 | ALDH1A1 (0.51) | TSHRCYP19A1CES2CES1MEN1 | |
| SCHEMBL2566022 | 0.83 | ALDH1A1 (0.51) | TSHRCYP19A1CES2CES1MEN1 | |
| SCHEMBL11640891 | 0.81 | SMN1; SMN2 (0.53) | ERCC5FEN1NPC1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922716-A | 5H-indeno 1,2-b!pyrazine-2,3-dione derivatives, their preparation and medicinal products containing them | RHONE-POULENC RORER S.A. (FR) | 1999-07-13 | — | — | US | disclosed |
| EP-0752988-B1 | 5H-INDENO[1,2-b]PYRAZINE-2,3-DIONE DERIVATIVES ANTAGONISTS OF AMPA AND NMDA RECEPTORS | RHONE POULENC RORER SA (FR) | 1999-05-26 | — | — | EP | disclosed |
| EP-0752988-A1 | 5H-INDENO[1,2-b]PYRAZINE-2,3-DIONE DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | Aventis Pharma S.A. (FR) | 1997-01-15 | — | — | EP | disclosed |
| WO-1995026342-A1 | 5H-INDENO[1,2-b]PYRAZINE-2,3-DIONE DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1995-10-05 | — | — | WO | disclosed |