Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5632220 | 0.95 | MAPT (0.53) | MAPTHRH3SIRT6ALDH1A1POLB | |
| SCHEMBL5166507 | 0.82 | MAPT (0.57) | MAPTHRH3SIRT6ALDH1A1POLB | |
| SCHEMBL85664 | 0.81 | MAPT (0.60) | MAPTHRH3SIRT6ALDH1A1POLB | |
| SCHEMBL77999 | 0.77 | MEN1 (0.56) | MAPTSIRT6ALDH1A1POLBADRB1 | |
| SCHEMBL29929946 | 0.77 | MEN1 (0.56) | MAPTSIRT6ALDH1A1POLBADRB1 | |
| SCHEMBL3868815 | 0.75 | ALDH1A1 (0.48) | MAPTALDH1A1POLBLMNAMEN1 | |
| SCHEMBL14881010 | 0.74 | MAPT (0.51) | MAPTHRH3SIRT6ALDH1A1POLB | |
| SCHEMBL378458 | 0.73 | MAPT (0.96) | MAPTSIRT6ALDH1A1POLBADRB1 | |
| SCHEMBL11183530 | 0.73 | MAPT (0.53) | MAPTSIRT6ALDH1A1POLBADRB1 | |
| SCHEMBL223626 | 0.72 | MAPT (1.00) | MAPTSIRT6ALDH1A1POLBADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579346-B2 | (R)-2-[(5-chlorothiophene-2-carbonyl)amino]-N-[3-methyl-4-(3-oxomorpholin-4-yl)phenyl]4-methylvaleramide, for example; inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors | MERCK PATENT GMBH (DE) | 2009-08-25 | — | — | US | disclosed |
| EP-1562939-B1 | CARBOXAMIDES | MERCK PATENT GMBH (DE) | 2009-01-21 | — | — | EP | disclosed |
| WO-2004046138-A1 | CARBOXAMIDES | MERCK PATENT GMBH (DE) | 2004-06-03 | — | — | WO | disclosed |