SCHEMBL8317419

SCHEMBL8317419

CN(C)c1ccc(C(=O)c2cccc(C3OCCO3)c2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 4/20 0.54
NPC1 O15118 4/20 0.54
RAB9A P51151 3/20 0.54
ALDH1A1 P00352 4/20 0.51
MAPT P10636 3/20 0.51
KCNK3 O14649 2/20 0.41
SMN1; SMN2 Q16637 4/20 0.40
KMT2A Q03164 2/20 0.40
TP53 P04637 2/20 0.40
MEN1 O00255 1/20 0.40
HRH3 Q9Y5N1 1/20 0.39
KDM4E B2RXH2 2/20 0.39
POLB P06746 2/20 0.39
LMNA P02545 2/20 0.39
TSHR P16473 1/20 0.39
HSD17B10 Q99714 1/20 0.39
PARP1 P09874 1/20 0.38
GAA P10253 1/20 0.38
NFKB1 P19838 1/20 0.38
HTT P42858 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5423204 0.85 PARP1 (0.49) HPGDNPC1RAB9AALDH1A1MAPT
SCHEMBL2539492 0.84 ATM (0.55) HPGDNPC1RAB9AALDH1A1MAPT
SCHEMBL8324154 0.78 L3MBTL1 (0.54) HPGDNPC1RAB9AALDH1A1MAPT
SCHEMBL4246223 0.76 PARP1 (0.46) HPGDNPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL1072468 0.76 HPGD (0.72) HPGDNPC1RAB9AALDH1A1MAPT
SCHEMBL2282510 0.75 KMO (0.56) HPGDRAB9AALDH1A1MAPTSMN1; SMN2
SCHEMBL6155001 0.74 SRD5A2 (0.55) HPGDALDH1A1MAPTKMT2AMEN1
SCHEMBL8317963 0.74 S1PR2 (0.44) NPC1RAB9AALDH1A1MAPTKCNK3
SCHEMBL13901589 0.73 PARP1 (0.46) NPC1RAB9AALDH1A1TSHRPARP1
SCHEMBL6697278 0.73 PARP1 (0.68) MAPTHRH3POLBTSHRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004071401-A2 HYDROXAMIC ACID DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS (HDCA) FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-08-26 WO disclosed