Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.65 |
| ▸ | RAB9A | P51151 | 9/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | CASP3 | P42574 | 1/20 | 0.59 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.59 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.59 |
| ▸ | RELA | Q04206 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.59 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2494059 | 0.89 | CSF1R (0.67) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4250694 | 0.86 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL13187385 | 0.85 | KMT2A (0.74) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2498464 | 0.83 | KCNK3 (0.66) | RAB9AKMT2AMEN1KCNK3HTT | |
| SCHEMBL6802691 | 0.80 | KMT2A (0.78) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL1811680 | 0.80 | L3MBTL1 (0.82) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8313843 | 0.80 | AVPR2 (0.61) | NPC1RAB9ASMN1; SMN2HPGDMAPT | |
| Hydrochloric Acid SCHEMBL2106088 | 0.79 | L3MBTL1 (0.80) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL27316696 | 0.78 | AVPR2 (0.54) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL14389500 | 0.78 | KMT2A (0.49) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636625-B1 | Tricyclic diazepines vasopressin and oxytocin antagonists | AMERICAN CYANAMID CO (US) | 1999-01-27 | — | — | EP | disclosed |
| CN-1205335-A | Tricyclic diazepine vasopression antagonists | AMERICAN CYANAMID CO (US) | 1999-01-20 | — | — | CN | disclosed |
| CN-1039908-C | Tricyclic diaza * vasopressin antagonists and oxytocin antagonists | AMERICAN CYANAMID CO (US) | 1998-09-23 | — | — | CN | disclosed |