Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.78 |
| ▸ | MEN1 | O00255 | 5/20 | 0.78 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.77 |
| ▸ | NPC1 | O15118 | 7/20 | 0.75 |
| ▸ | RAB9A | P51151 | 7/20 | 0.75 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.69 |
| ▸ | MITF | O75030 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | CASP3 | P42574 | 1/20 | 0.64 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.64 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 2/20 | 0.60 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.60 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8770869 | 0.89 | KMT2A (0.72) | KMT2AMEN1L3MBTL1NPC1RAB9A | |
| SCHEMBL30739642 | 0.88 | KMT2A (0.86) | KMT2AMEN1L3MBTL1NPC1RAB9A | |
| SCHEMBL6027951 | 0.88 | MEN1 (0.88) | KMT2AMEN1L3MBTL1NPC1RAB9A | |
| SCHEMBL30643220 | 0.88 | MEN1 (0.88) | KMT2AMEN1L3MBTL1NPC1RAB9A | |
| SCHEMBL9067770 | 0.88 | KMT2A (1.00) | KMT2AMEN1L3MBTL1NPC1RAB9A | |
| SCHEMBL1811680 | 0.87 | L3MBTL1 (0.82) | KMT2AMEN1L3MBTL1NPC1RAB9A | |
| SCHEMBL8734134 | 0.87 | KCNK3 (0.76) | KMT2AMEN1L3MBTL1NPC1RAB9A | |
| SCHEMBL2058359 | 0.86 | KMT2A (0.96) | KMT2AMEN1L3MBTL1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL2106088 | 0.86 | L3MBTL1 (0.80) | KMT2AMEN1L3MBTL1NPC1RAB9A | |
| SCHEMBL16404741 | 0.86 | HDAC6 (0.75) | KMT2AMEN1L3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828427-B1 | Oligomeric aminodiol-containing compounds, libraries thereof, and process of preparing the same | ISIS PHARMACEUTICALS, INC. | 2004-12-07 | — | — | US | disclosed |
| US-6750344-B1 | MONOCYCLIC AMINE SCAFFOLD BEARING AT LEAST TWO SITES OF DIVERSITY, CYCLIZED TO FORM BICYCLIC AMINE SCAFFOLDS; 7-AMINO-PYRROLO(1,2-A)PYRAZIN-4-ONE COMPOUNDS | ISIS PHARMACEUTICALS, INC. | 2004-06-15 | — | — | US | disclosed |
| US-6316626-B1 | Amine compounds and combinatorial libraries comprising same | ISIS PHARMACEUTICALS, INC. | 2001-11-13 | — | — | US | disclosed |
| WO-1999012034-A1 | AMINE COMPOUNDS AND COMBINATORIAL LIBRARIES COMPRISING SAME | ISIS PHARMACEUTICALS, INC. (US) | 1999-03-11 | — | — | WO | disclosed |