Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 1/20 | 0.61 |
| ▸ | OXTR | P30559 | 1/20 | 0.61 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.61 |
| ▸ | PYGL | P06737 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | FADS1 | O60427 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.51 |
| ▸ | PNLIP | P16233 | 1/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.48 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7331533 | 0.86 | AVPR2 (0.79) | AVPR2OXTRAVPR1APYGLNPC1 | |
| SCHEMBL22871324 | 0.83 | AVPR2 (0.55) | AVPR2OXTRAVPR1APYGLNPC1 | |
| SCHEMBL7341264 | 0.81 | TSHR (0.68) | AVPR2PYGLNPC1RAB9ATDP1 | |
| SCHEMBL27316696 | 0.80 | AVPR2 (0.54) | AVPR2OXTRAVPR1ANPC1RAB9A | |
| SCHEMBL8317450 | 0.80 | NPC1 (0.65) | AVPR2OXTRAVPR1ANPC1RAB9A | |
| SCHEMBL8316833 | 0.78 | SMN1; SMN2 (0.61) | PYGLNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL12700230 | 0.78 | ALDH1A1 (0.64) | AVPR2OXTRAVPR1ANPC1RAB9A | |
| SCHEMBL1197393 | 0.78 | PYGL (0.64) | AVPR2OXTRAVPR1APYGLNPC1 | |
| SCHEMBL7334964 | 0.77 | AVPR2 (0.57) | AVPR2OXTRAVPR1ANPC1RAB9A | |
| SCHEMBL7824838 | 0.77 | FADS1 (0.72) | NPC1RAB9AFADS1NPSR1PNLIP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636625-B1 | Tricyclic diazepines vasopressin and oxytocin antagonists | AMERICAN CYANAMID CO (US) | 1999-01-27 | — | — | EP | disclosed |
| CN-1039908-C | Tricyclic diaza * vasopressin antagonists and oxytocin antagonists | AMERICAN CYANAMID CO (US) | 1998-09-23 | — | — | CN | disclosed |