SCHEMBL8317577

SCHEMBL8317577

O=[N+]([O-])C1(c2cccc(Br)c2)CC1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.36
MAPK1 P28482 1/20 0.36
CTSD P07339 1/20 0.35
BACE1 P56817 1/20 0.35
KDM1A O60341 1/20 0.34
GAA P10253 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
MAPT P10636 2/20 0.33
CHRNA1 P02708 1/20 0.33
CHRNG P07510 1/20 0.33
CHRNB1 P11230 1/20 0.33
CHRNB2 P17787 1/20 0.33
SLC6A2 P23975 1/20 0.33
CHRNB4 P30926 1/20 0.33
SLC6A4 P31645 1/20 0.33
CHRNA3 P32297 1/20 0.33
CHRNA4 P43681 1/20 0.33
SLC6A3 Q01959 1/20 0.33
CHRND Q07001 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3030130 0.79 CTSD (0.38) ALDH1A1CTSDBACE1GAASLC6A4
SCHEMBL3832335 0.77 ALDH1A1 (0.41) ALDH1A1MAPK1MAPTLMNAMEN1
SCHEMBL11461558 0.69 AKR1C1 (0.39) ALDH1A1LMNAMEN1KMT2A
SCHEMBL3032504 0.69 FBP1 (0.43) BACE1SLC6A2SLC6A4HSD11B1ALOX5
SCHEMBL30605863 0.68 CHRNA1 (0.35) ALDH1A1KDM1AGAASMN1; SMN2NPSR1
SCHEMBL29089796 0.68 CHRNA1 (0.35) ALDH1A1KDM1AGAASMN1; SMN2NPSR1
SCHEMBL7136098 0.68 ALDH1A1 (0.42) ALDH1A1MAPK1CTSDBACE1GAA
SCHEMBL7144286 0.68 CHRNA1 (0.42) ALDH1A1MAPK1CTSDBACE1GAA
SCHEMBL25350885 0.67 ALDH1A1 (0.38) ALDH1A1MAPK1CTSDBACE1KDM1A
SCHEMBL1556078 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0779888-B1 PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM BOEHRINGER INGELHEIM PHARMA (DE) 1999-04-28 EP disclosed
US-5707989-A ANTITUMOR AGENTS, INHIBITING SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES DR. KARL THOMAE GMBH (DE) 1998-01-13 US disclosed
EP-0779888-A1 PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM Dr. Karl Thomae GmbH (DE) 1997-06-25 EP disclosed
WO-1996007657-A1 PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM DR. KARL THOMAE GMBH (DE) 1996-03-14 WO disclosed