Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | NPY4R | P50391 | 9/20 | 0.37 |
| ▸ | NPY1R | P25929 | 6/20 | 0.37 |
| ▸ | NPY2R | P49146 | 4/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.33 |
| ▸ | TPH1 | P17752 | 1/20 | 0.32 |
| ▸ | ALPI | P09923 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | XIAP | P98170 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL8315939 | 1.00 | SLC7A5 (0.40) | SLC7A5ITGB3ITGA2BNPY4RNPY1R | |
| Histidine SCHEMBL2330373 | 0.97 | SLC7A5 (0.41) | SLC7A5ITGB3ITGA2BNPY4RNPY1R | |
| Arginine SCHEMBL8318272 | 0.96 | ITGB3 (0.43) | SLC7A5ITGB3ITGA2BNPY4RNPY1R | |
| Histidine SCHEMBL2331922 | 0.91 | NPY4R (0.37) | SLC7A5ITGB3ITGA2BNPY4RNPY1R | |
| SCHEMBL17363643 | 0.90 | FNTA (0.39) | SLC7A5ITGB3ITGA2BNPY4RNPY1R | |
| Tyrosine SCHEMBL27524500 | 0.88 | SLC7A5 (0.46) | SLC7A5NPY4RNPY1RNPY2RNPY5R | |
| Arginine SCHEMBL27971714 | 0.88 | ALPI (0.44) | SLC7A5NPY4RNPY1RNPY2RNPY5R | |
| Arginine SCHEMBL23242196 | 0.87 | OTC (0.38) | SLC7A5NPY4RNPY1RNPY2RNPY5R | |
| Arginine SCHEMBL15194711 | 0.87 | OTC (0.38) | SLC7A5NPY4RNPY1RNPY2RNPY5R | |
| Arginine SCHEMBL1537331 | 0.87 | OTC (0.38) | SLC7A5NPY4RNPY1RNPY2RNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0744614-B1 | Use of Isoelectric point markers for isoelectric focusing with fluorescence detection | LAB MOLECULAR BIOPHOTONICS (JP) | 1999-12-22 | — | — | EP | disclosed |
| US-5866683-A | Isoelectric point markers for isoelectric focusing with fluorescence detection | LABORATORY OF MOLECULAR BIOPHOTONICS (JP) | 1999-02-02 | — | — | US | disclosed |
| EP-0744614-A2 | Isoelectric point markers for isoelectric focusing with fluorescence detection | Laboratory of Molecular Biophotonics (JP) | 1996-11-27 | — | — | EP | disclosed |