Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY4R | P50391 | 11/20 | 0.37 |
| ▸ | NPY1R | P25929 | 6/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 4/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.33 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.33 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.33 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.33 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.33 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.33 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL2330373 | 0.94 | SLC7A5 (0.41) | NPY4RNPY1RSLC7A5ITGB3ITGA2B | |
| Arginine SCHEMBL8317787 | 0.91 | SLC7A5 (0.40) | NPY4RNPY1RSLC7A5ITGB3ITGA2B | |
| Arginine SCHEMBL8315939 | 0.91 | SLC7A5 (0.40) | NPY4RNPY1RSLC7A5ITGB3ITGA2B | |
| Arginine SCHEMBL8318272 | 0.89 | ITGB3 (0.43) | NPY4RNPY1RSLC7A5ITGB3ITGA2B | |
| Histidine SCHEMBL4778276 | 0.88 | NPY4R (0.40) | NPY4RNPY1RSLC7A5ITGB3ITGA2B | |
| SCHEMBL17363643 | 0.86 | FNTA (0.39) | NPY4RNPY1RSLC7A5ITGB3ITGA2B | |
| Glycine SCHEMBL5579222 | 0.86 | ITGB3 (0.45) | NPY4RNPY1RSLC7A5ITGB3ITGA2B | |
| Arginine SCHEMBL28861125 | 0.85 | ALPI (0.41) | NPY4RNPY1RSLC7A5NPY2RNPY5R | |
| Valine SCHEMBL16992661 | 0.84 | NPY4R (0.35) | NPY4RNPY1RSLC7A5ITGB3ITGA2B | |
| Arginine SCHEMBL21612207 | 0.84 | OTC (0.35) | NPY4RNPY1RSLC7A5NPY2RNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170267736-A1 | IGF-I POLY (ETHYLENE GLYCOL) CONJUGATES | HOFFMANN-LA ROCHE INC. | 2017-09-21 | — | — | US | disclosed |
| US-9587006-B2 | IGF-I poly (ethylene glycol) conjugates | HOFFMANN-LA ROCHE INC. (US) | 2017-03-07 | — | — | US | disclosed |
| US-20120309679-A1 | IGF-I POLY (ETHYLENE GLYCOL) CONJUGATES | HOFFMANN-LA ROCHE INC. | 2012-12-06 | — | — | US | disclosed |
| WO-2011098400-A1 | IGF-I POLY (ETHYLENE GLYCOL) CONJUGATES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-08-18 | — | — | WO | disclosed |