Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RYR2 | Q92736 | 4/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 4/20 | 0.39 |
| ▸ | DRD5 | P21918 | 4/20 | 0.39 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | DRD3 | P35462 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6492438 | 0.77 | BRD4 (0.38) | DRD2DRD3KDM4E | |
| SCHEMBL6984360 | 0.70 | — | — | |
| SCHEMBL26023478 | 0.69 | CA2 (0.48) | RYR2MAOAMAOBPDE3BPDE3A | |
| SCHEMBL19957149 | 0.65 | PDE3B (0.48) | MAOAMAOBPDE3BPDE3ATIPARP | |
| SCHEMBL12043662 | 0.65 | KCNH2 (0.49) | ADAM17KDM4EMAPTKMT2A | |
| SCHEMBL12367363 | 0.64 | DRD1 (0.47) | RYR2DRD1DRD5TIPARPDRD2 | |
| SCHEMBL26768689 | 0.63 | METAP1 (0.44) | RYR2DRD1DRD5DRD2DRD3 | |
| SCHEMBL6606073 | 0.63 | PDE3B (0.56) | RYR2MAOAMAOBPDE3BPDE3A | |
| SCHEMBL17341937 | 0.62 | NAMPT (0.53) | RYR2CA1CA2CA7CA9 | |
| SCHEMBL8994250 | 0.61 | PDE3B (0.59) | MAOAMAOBPDE3BPDE3ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929072-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY LIMITED (GB) | 1999-07-27 | — | — | US | disclosed |
| EP-0897921-A1 | Benzothiadiazinyl-indole derivatives and their use as serotonin receptor ligands | ELI LILLY AND COMPANY LIMITED (GB) | 1999-02-24 | — | — | EP | disclosed |