Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5145030 | 0.87 | AKR1C3 (0.50) | NR4A1KMT2AMAPTSRD5A2L3MBTL1 | |
| SCHEMBL11445577 | 0.82 | S100B (0.58) | NR4A1KMT2AMAPTMAPK1ALDH1A1 | |
| SCHEMBL3444656 | 0.77 | NR4A1 (0.84) | NR4A1KMT2AMAPTCES2CES1 | |
| SCHEMBL21847220 | 0.77 | NR4A1 (0.45) | NR4A1KMT2AMAPTSRD5A2MAPK1 | |
| SCHEMBL6573452 | 0.76 | ALDH1A1 (0.44) | MAPTCES2CES1ALDH1A1CYP1A2 | |
| SCHEMBL29498981 | 0.75 | AKR1C3 (0.44) | NR4A1MAPTL3MBTL1ALDH1A1CYP2C9 | |
| SCHEMBL28285905 | 0.75 | AKR1C3 (0.44) | NR4A1MAPTL3MBTL1ALDH1A1CYP2C9 | |
| SCHEMBL11492387 | 0.75 | RECQL (0.57) | KMT2AMAPTCES2CES1ALDH1A1 | |
| SCHEMBL1110888 | 0.74 | ALDH1A1 (0.50) | NR4A1KMT2AMAPTMAPK1L3MBTL1 | |
| SCHEMBL28451754 | 0.74 | NR4A1 (0.85) | NR4A1MAPTCES2CES1SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934940-A1 | CYTOKINE PRODUCTION INHIBITORS, TRIAZEPINE COMPOUNDS, AND INTERMEDIATES THEREOF | Japan Tobacco Inc. (JP) | 1999-08-11 | — | — | EP | disclosed |
| US-5807850-A | Therapeutic agent for osteoporosis and triazepine compound | JAPAN TOBACCO, INC. (JP) | 1998-09-15 | — | — | US | disclosed |
| EP-0792880-A1 | OSTEOPOROSIS REMEDY AND TRIAZEPINE COMPOUND | Japan Tobacco Inc. (JP) | 1997-09-03 | — | — | EP | disclosed |