Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9197019 | 0.84 | ESR1 (0.56) | TYRKMT2AMAPTCYP2C9CYP2D6 | |
| SCHEMBL4658430 | 0.83 | TYR (0.54) | TYRTAAR1KMT2AMEN1MAPT | |
| SCHEMBL10999500 | 0.79 | ALDH1A1 (0.39) | TYRCYP2D6ALDH1A1 | |
| SCHEMBL3422118 | 0.79 | CYP3A4 (0.37) | TYRADRA2AADRA2CCYP2D6LMNA | |
| SCHEMBL10597086 | 0.78 | TYR (0.33) | TYRCYP2D6 | |
| SCHEMBL10862066 | 0.77 | GABRA1 (0.43) | KMT2AMAPTLMNAHIF1AALDH1A1 | |
| SCHEMBL16632474 | 0.76 | SLC6A2 (0.41) | TAAR1KMT2AMEN1MAPTCYP2C9 | |
| SCHEMBL16632702 | 0.76 | SLC6A2 (0.41) | TAAR1KMT2ACYP2C9CYP2D6ALDH1A1 | |
| SCHEMBL4156669 | 0.76 | TYR (0.48) | TYRTAAR1KMT2AMEN1MAPT | |
| SCHEMBL3819120 | 0.76 | TYR (0.48) | TYRTAAR1KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929534-A1 | TRYCYCLIC COMPOUNDS AS PROSTAGLANDIN I2 RECEPTOR AGONISTS | Takeda Pharmaceutical Company Limited (JP) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998013356-A1 | TRYCYCLIC COMPOUNDS AS PROSTAGLANDIN I2 RECEPTOR AGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-04-02 | — | — | WO | disclosed |