Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.61 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.61 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.61 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.61 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.61 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.48 |
| ▸ | PTAFR | P25105 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316669 | 0.87 | OPRK1 (0.61) | GABRA1GABRA5GABRA3GABRA2OPRK1 | |
| Bromide SCHEMBL8319843 | 0.86 | OPRK1 (0.60) | GABRA1GABRA5GABRA3GABRA2OPRK1 | |
| SCHEMBL8318668 | 0.79 | BRD4 (0.59) | GABRA1GABRA5GABRA3GABRA2OPRK1 | |
| Triazolam SCHEMBL29382425 | 0.76 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2OPRK1 | |
| Triazolam SCHEMBL5142333 | 0.76 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2OPRK1 | |
| Triazolam SCHEMBL29349744 | 0.76 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2OPRK1 | |
| Triazolam SCHEMBL29228 | 0.76 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2OPRK1 | |
| Triazolam SCHEMBL29368430 | 0.76 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2OPRK1 | |
| Triazolam SCHEMBL9055695 | 0.75 | GABRA1 (0.98) | GABRA1GABRA5GABRA3GABRA2OPRK1 | |
| Triazolam SCHEMBL27600059 | 0.75 | GABRA1 (0.98) | GABRA1GABRA5GABRA3GABRA2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934940-A1 | CYTOKINE PRODUCTION INHIBITORS, TRIAZEPINE COMPOUNDS, AND INTERMEDIATES THEREOF | Japan Tobacco Inc. (JP) | 1999-08-11 | — | — | EP | disclosed |
| US-5807850-A | Therapeutic agent for osteoporosis and triazepine compound | JAPAN TOBACCO, INC. (JP) | 1998-09-15 | — | — | US | disclosed |
| EP-0792880-A1 | OSTEOPOROSIS REMEDY AND TRIAZEPINE COMPOUND | Japan Tobacco Inc. (JP) | 1997-09-03 | — | — | EP | disclosed |