Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.35 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.35 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319383 | 0.97 | HPGD (0.43) | HPGDNPSR1KDM4ESMN1; SMN2GPBAR1 | |
| SCHEMBL8321061 | 0.90 | HPGD (0.41) | HPGDNPSR1KDM4ESMN1; SMN2GPBAR1 | |
| SCHEMBL8462232 | 0.86 | KDM4E (0.41) | KDM4EALDH1A1POLBGAA | |
| SCHEMBL8317255 | 0.83 | GAA (0.45) | HPGDNPSR1KDM4EALDH1A1POLB | |
| SCHEMBL8323456 | 0.81 | TSHR (0.39) | HPGDNPSR1KDM4EALDH1A1GLA | |
| SCHEMBL8318729 | 0.80 | GAA (0.44) | HPGDNPSR1KDM4EALDH1A1POLB | |
| SCHEMBL8318029 | 0.79 | ALDH1A1 (0.46) | HPGDNPSR1KDM4EALDH1A1GLA | |
| SCHEMBL8323687 | 0.75 | HPGD (0.55) | HPGDNPSR1KDM4ESMN1; SMN2GPBAR1 | |
| SCHEMBL8320504 | 0.74 | CYP2C9 (0.37) | HPGDNPSR1KDM4EALDH1A1GLA | |
| SCHEMBL8318733 | 0.73 | HPGD (0.43) | HPGDNPSR1KDM4ESMN1; SMN2GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0717043-B1 | Use of 1,2-bridged 1,4-dihydropyridines as selective potassium channel modulators | BAYER AG (DE) | 1999-11-10 | — | — | EP | claimed |
| EP-0717043-A1 | Use of 1,2-bridged 1,4-dihydropyridines as selective potassium channel modulators | BAYER AG (DE) | 1996-06-19 | — | — | EP | claimed |