Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.69 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.69 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.65 |
| ▸ | S100B | P04271 | 1/20 | 0.65 |
| ▸ | BRAF | P15056 | 1/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.53 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.53 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.53 |
| ▸ | ABAT | P80404 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319294 | 1.00 | PTGS2 (0.69) | PTGS2PTGS1NFE2L2S100BBRAF | |
| SCHEMBL28507952 | 0.88 | PTGS2 (0.69) | PTGS2PTGS1CXCL12MAPTALDH1A1 | |
| SCHEMBL29351511 | 0.88 | S100B (0.69) | PTGS2PTGS1S100BALOX5CA12 | |
| SCHEMBL8325328 | 0.86 | S100B (0.66) | PTGS2PTGS1NFE2L2S100BCA12 | |
| SCHEMBL28607191 | 0.86 | PTGS2 (0.65) | PTGS2PTGS1S100BCA12CA2 | |
| SCHEMBL8325327 | 0.86 | S100B (0.66) | PTGS2PTGS1NFE2L2S100BCA12 | |
| SCHEMBL31318312 | 0.85 | PTGS2 (0.66) | PTGS2PTGS1NFE2L2MAPTALDH1A1 | |
| SCHEMBL10486517 | 0.84 | PTGS2 (0.64) | PTGS2PTGS1MAPTGAAALDH1A1 | |
| SCHEMBL10486520 | 0.84 | PTGS2 (0.64) | PTGS2PTGS1MAPTGAAALDH1A1 | |
| SCHEMBL16885013 | 0.84 | PTGS2 (0.64) | PTGS2PTGS1NFE2L2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990137-A | ANTIINFLAMMATION AGENTS; PREVENTING THE OXIDATING BURST FROM PHAGOCYTIC LEUKOCYTES; CONTROLLING FREE RADICALS IN THE IMMUNE RESPONSE | IDUN PHARMACEUTICALS, INC. (US) | 1999-11-23 | — | — | US | disclosed |
| US-5939460-A | Method of inhibiting NADPH oxidase | IDUN PHARMACEUTICALS, INC. (US) | 1999-08-17 | — | — | US | disclosed |
| WO-1998001120-A1 | METHOD OF INHIBITING NADPH OXIDASE | IDUN PHARMACEUTICALS, INCORPORATED (US) | 1998-01-15 | — | — | WO | disclosed |