Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | CCKBR | P32239 | 5/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.43 |
| ▸ | GALR3 | O60755 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALB | P02768 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24246717 | 0.87 | GABRA1 (0.55) | CCKBRGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL11543658 | 0.75 | GABRA1 (0.78) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2526769 | 0.72 | CCKBR (0.56) | CCKBRLMNAMEN1KMT2AALB | |
| SCHEMBL4796036 | 0.72 | CCKBR (0.56) | CCKBRLMNAMEN1KMT2AALB | |
| SCHEMBL9288154 | 0.72 | CCKBR (0.45) | CCKBRGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL8315954 | 0.71 | CCKBR (0.43) | CCKBRGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL11899990 | 0.70 | CCKBR (0.78) | CCKBRCCKAR | |
| SCHEMBL4416283 | 0.69 | CCKBR (0.57) | BRD4CCKBRLMNAMEN1KMT2A | |
| SCHEMBL11191379 | 0.69 | CHRM1 (0.71) | BRD4GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL9321987 | 0.68 | MAOA (0.52) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934940-A1 | CYTOKINE PRODUCTION INHIBITORS, TRIAZEPINE COMPOUNDS, AND INTERMEDIATES THEREOF | Japan Tobacco Inc. (JP) | 1999-08-11 | — | — | EP | disclosed |
| EP-0792880-A1 | OSTEOPOROSIS REMEDY AND TRIAZEPINE COMPOUND | Japan Tobacco Inc. (JP) | 1997-09-03 | — | — | EP | disclosed |