Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 4/20 | 0.44 |
| ▸ | PREP | P48147 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | CPB1 | P15086 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320291 | 1.00 | NAAA (0.44) | NAAAPREPALDH1A1GAATSHR | |
| SCHEMBL8319092 | 1.00 | NAAA (0.44) | NAAAPREPALDH1A1GAATSHR | |
| SCHEMBL8319502 | 1.00 | NAAA (0.44) | NAAAPREPALDH1A1GAATSHR | |
| SCHEMBL19576770 | 0.75 | NAAA (0.54) | NAAAPREPALDH1A1GAATSHR | |
| SCHEMBL14601914 | 0.73 | CTSK (0.54) | NAAAPREPALDH1A1GAATSHR | |
| SCHEMBL13017770 | 0.73 | NAAA (0.50) | NAAAPREPALDH1A1GAATSHR | |
| SCHEMBL12345121 | 0.73 | NAAA (0.50) | NAAAPREPALDH1A1GAATSHR | |
| SCHEMBL15200070 | 0.73 | NAAA (0.52) | NAAAPREPALDH1A1GAATSHR | |
| SCHEMBL13043801 | 0.73 | CTSK (0.54) | NAAAPREPALDH1A1GAATSHR | |
| SCHEMBL13043811 | 0.71 | CASP3 (0.53) | NAAAALDH1A1GAACTSKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342007-B2 | Lactams and uses thereof | ASTRAZENECA AB (SE) | 2008-03-11 | — | — | US | disclosed |
| US-7342007-B2 | Lactams and uses thereof | ASTRAZENECA AB (SE) | 2008-03-11 | — | — | US | disclosed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | disclosed |