Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.73 |
| ▸ | PRTN3 | P24158 | 2/20 | 0.73 |
| ▸ | CTSG | P08311 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5257643 | 0.83 | ELANE (0.73) | ELANEPRTN3CTSGMAPTNPSR1 | |
| SCHEMBL28548453 | 0.71 | KDM4E (0.60) | MAPTSMN1; SMN2GAAKMT2ALMNA | |
| SCHEMBL1432439 | 0.71 | GABRA1 (0.50) | ELANEPRTN3CTSGNPSR1HPGD | |
| Ethadione SCHEMBL35279 | 0.70 | ELANE (0.55) | ELANEPRTN3CTSGMAPTNPSR1 | |
| SCHEMBL4914804 | 0.70 | ELANE (0.63) | ELANEPRTN3CTSGTSHRTP53 | |
| SCHEMBL5006337 | 0.69 | ELANE (0.54) | ELANEPRTN3CTSGLMNAALDH1A1 | |
| SCHEMBL7309157 | 0.69 | ELANE (0.53) | ELANEPRTN3CTSGGRM2LMNA | |
| SCHEMBL12704514 | 0.69 | TP53 (0.53) | MAPTTP53SMN1; SMN2GAAKMT2A | |
| SCHEMBL4757301 | 0.69 | ELANE (0.53) | ELANEPRTN3CTSGGRM2LMNA | |
| SCHEMBL4800190 | 0.69 | MGLL (0.78) | MAPTTP53SMN1; SMN2GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592426-B1 | 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2007-12-19 | — | — | EP | disclosed |
| WO-2004069256-A1 | 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2004-08-19 | — | — | WO | disclosed |