Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 14/20 | 0.52 |
| ▸ | PHGDH | O43175 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20080888 | 0.92 | NOTUM (0.58) | NOTUMPHGDHMEN1CYP1A2CYP3A4 | |
| SCHEMBL8320138 | 0.84 | SIRT6 (0.59) | NOTUMPHGDHMEN1CYP1A2CYP3A4 | |
| SCHEMBL3805648 | 0.82 | NOTUM (0.61) | NOTUMPHGDHMEN1CYP1A2CYP3A4 | |
| SCHEMBL3243736 | 0.81 | NOTUM (0.53) | NOTUMPHGDHMEN1CYP1A2CYP3A4 | |
| SCHEMBL255333 | 0.81 | ADRB1 (0.65) | NOTUMCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2921346 | 0.80 | DPP4 (0.51) | NOTUMPHGDHMEN1CYP1A2CYP3A4 | |
| SCHEMBL6240445 | 0.80 | NOTUM (0.49) | NOTUMPHGDHMEN1CYP1A2CYP3A4 | |
| SCHEMBL13801246 | 0.80 | NOTUM (0.52) | NOTUMPHGDHMEN1CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL1637829 | 0.79 | ADRB1 (0.63) | NOTUMCYP1A2CYP3A4CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL11185302 | 0.79 | ADRB1 (0.63) | NOTUMCYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5945421-A | TREATING PSYCHOSIS AND SCHIZOPHRENIA | WARNER-LAMBERT COMPANY (US) | 1999-08-31 | — | — | US | disclosed |