SCHEMBL8320385

SCHEMBL8320385

Brc1ccc(OCc2ccccc2)c(CCc2ccc(-c3nnn[nH]3)cc2)c1

nearest known ligand 0.45

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CCR5 P51681 5/20 0.45
HTT P42858 3/20 0.44
ALDH1A1 P00352 3/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
USP28 Q96RU2 1/20 0.44
USP25 Q9UHP3 1/20 0.44
RAB9A P51151 1/20 0.44
HTR1A P08908 1/20 0.44
DRD2 P14416 1/20 0.44
LMNA P02545 2/20 0.43
ABCB1 P08183 3/20 0.42
PTGER1 P34995 3/20 0.41
ABCG2 Q9UNQ0 1/20 0.41
CYP1A2 P05177 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8409051 1.00 CCR5 (0.45) CCR5HTTALDH1A1SMN1; SMN2USP28
SCHEMBL8409574 0.88 HTR1A (0.45) HTR1ADRD2ABCB1PTGER1ABCG2
SCHEMBL8322241 0.87 HTR1A (0.44) HTTALDH1A1SMN1; SMN2HTR1ADRD2
SCHEMBL8405902 0.87 HTR1A (0.44) HTTALDH1A1SMN1; SMN2HTR1ADRD2
SCHEMBL8408170 0.87 HTR1A (0.61) HTR1ADRD2ABCB1PTGER1ABCG2
SCHEMBL8320664 0.87 HTR1A (0.61) HTR1ADRD2ABCB1PTGER1ABCG2
SCHEMBL8406776 0.85 ABCB1 (0.55) HTR1ADRD2ABCB1ABCG2
SCHEMBL8324773 0.83 SYK (0.43) ALDH1A1HTR1ADRD2ABCB1PTGER1
SCHEMBL8166840 0.82 CCR5 (0.45) CCR5HTTALDH1A1SMN1; SMN2USP28
SCHEMBL8406943 0.81 HTR1A (0.65) CCR5HTTALDH1A1SMN1; SMN2USP28

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0733033-B1 PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS ZENECA LTD (GB) 1999-12-22 EP claimed
EP-0733033-A1 PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS ZENECA LIMITED (GB) 1996-09-25 EP claimed
WO-1996011902-A1 PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS ZENECA LIMITED (GB) 1996-04-25 WO claimed
EP-0733033-B1 PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS ZENECA LTD (GB) 1999-12-22 EP disclosed
US-5811459-A PAIN RELIEVERS ZENECA LIMITED (GB) 1998-09-22 US disclosed
EP-0733033-A1 PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS ZENECA LIMITED (GB) 1996-09-25 EP disclosed
WO-1996011902-A1 PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS ZENECA LIMITED (GB) 1996-04-25 WO disclosed