SCHEMBL8409574

SCHEMBL8409574

Oc1ccc(OCc2ccc(-c3nnn[nH]3)cc2)c(CCc2ccccc2)c1

nearest known ligand 0.45

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 4/20 0.45
DRD2 P14416 4/20 0.45
ABCB1 P08183 6/20 0.43
ABCG2 Q9UNQ0 1/20 0.42
SLC2A1 P11166 1/20 0.41
ELANE P08246 4/20 0.40
F2 P00734 1/20 0.40
BCHE P06276 2/20 0.38
CTSG P08311 1/20 0.37
PTGER1 P34995 1/20 0.37
PTGER4 P35408 1/20 0.37
PTGER3 P43115 1/20 0.37
PTGER2 P43116 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8322241 0.88 HTR1A (0.44) HTR1ADRD2ABCB1ABCG2PTGER1
SCHEMBL8405902 0.88 HTR1A (0.44) HTR1ADRD2ABCB1ABCG2PTGER1
SCHEMBL8409051 0.88 CCR5 (0.45) HTR1ADRD2ABCB1ABCG2PTGER1
SCHEMBL8320385 0.88 CCR5 (0.45) HTR1ADRD2ABCB1ABCG2PTGER1
SCHEMBL8320664 0.88 HTR1A (0.61) HTR1ADRD2ABCB1ABCG2PTGER1
SCHEMBL8408170 0.88 HTR1A (0.61) HTR1ADRD2ABCB1ABCG2PTGER1
SCHEMBL8406776 0.86 ABCB1 (0.55) HTR1ADRD2ABCB1ABCG2
SCHEMBL8324773 0.86 SYK (0.43) HTR1ADRD2ABCB1ABCG2PTGER1
SCHEMBL8325617 0.81 PTGER1 (0.55) HTR1ADRD2ABCB1ABCG2PTGER1
SCHEMBL30628475 0.81 HTR1A (0.67) HTR1ADRD2ABCB1ABCG2SLC2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0778821-B1 ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF ZENECA LTD (GB) 1999-10-20 EP claimed
EP-0778821-A1 ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF ZENECA LIMITED (GB) 1997-06-18 EP claimed
WO-1996006822-A1 ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF ZENECA LIMITED (GB) 1996-03-07 WO claimed
EP-0778821-B1 ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF ZENECA LTD (GB) 1999-10-20 EP disclosed
US-5965741-A ANTIINFLAMMATORY, ANTIPYRETIC AND ANTIDIARRHOEAL PROPERTIES ZENECA LIMITED (GB) 1999-10-12 US disclosed
EP-0778821-A1 ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF ZENECA LIMITED (GB) 1997-06-18 EP disclosed
WO-1996006822-A1 ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF ZENECA LIMITED (GB) 1996-03-07 WO disclosed