Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.50 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.48 |
| ▸ | S100B | P04271 | 1/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.45 |
| ▸ | TUBB | P07437 | 1/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.45 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.45 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.45 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.45 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.45 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.45 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.45 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.45 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320519 | 1.00 | PTGS2 (0.63) | PTGS2MAPTGAAKMT2AKDM4E | |
| SCHEMBL8321666 | 0.85 | PTGS2 (0.65) | PTGS2MAPTGAAKMT2AKDM4E | |
| SCHEMBL8325328 | 0.85 | S100B (0.66) | PTGS2MAPTGAAKMT2APTGS1 | |
| SCHEMBL8325327 | 0.85 | S100B (0.66) | PTGS2MAPTGAAKMT2APTGS1 | |
| SCHEMBL8321668 | 0.85 | PTGS2 (0.65) | PTGS2MAPTGAAKMT2AKDM4E | |
| SCHEMBL28964170 | 0.85 | PTGS2 (0.65) | PTGS2MAPTGAAKMT2AKDM4E | |
| SCHEMBL8319560 | 0.84 | PTGS2 (0.63) | PTGS2MAPTGAAKMT2AKDM4E | |
| SCHEMBL8319558 | 0.84 | PTGS2 (0.63) | PTGS2MAPTGAAKMT2AKDM4E | |
| SCHEMBL8575456 | 0.79 | PTGS2 (0.58) | PTGS2MAPTGAAKMT2AKDM4E | |
| SCHEMBL8575451 | 0.79 | PTGS2 (0.58) | PTGS2MAPTGAAKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990137-A | ANTIINFLAMMATION AGENTS; PREVENTING THE OXIDATING BURST FROM PHAGOCYTIC LEUKOCYTES; CONTROLLING FREE RADICALS IN THE IMMUNE RESPONSE | IDUN PHARMACEUTICALS, INC. (US) | 1999-11-23 | — | — | US | disclosed |
| US-5939460-A | Method of inhibiting NADPH oxidase | IDUN PHARMACEUTICALS, INC. (US) | 1999-08-17 | — | — | US | disclosed |
| WO-1998001120-A1 | METHOD OF INHIBITING NADPH OXIDASE | IDUN PHARMACEUTICALS, INCORPORATED (US) | 1998-01-15 | — | — | WO | disclosed |